Description: Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention. TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume II presents practical methodologies involving models for disorders of the cardiovascular system, the brain, skin, the metabolic system, as well as colitis, cancer, thermosensation, and musculoskeletal disorders. Written for the Methods in Pharmacology and Toxicology(TM) series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab. Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline. Part I: TRPs and Cardiovascular Disease 1. TRPs to Cardiovascular Disease José C. González-Cobos, Xuexin Zhang, Rajender K. Motiani, Kelly E. Harmon, and Mohamed Trebak 2. Anemic Zebrafish Models of Cardiomyopathy Xiaojing Sun and Xiaolei Xu 3. Methods to Study the Effects of TRP Channel Drugs on Vascular Endothelial Cell Function Yan Ma, Yung-Wui Tjong, and Xiaoqiang Yao 4. Atherosclerosis Models with Cell-Mediated Calcification Beili Zhu 5. Models of Hypertension and Blood Pressure Recording Luciana Aparecida Campos and Ovidiu Constantin Baltatu 6. Balloon Injury in Rats as a Model for Studying TRP Channel Contribution to Vascular Smooth Muscle Remodeling Wei Zhang and Mohamed Trebak Part II: TRPs and the Brain 7. TRP Channels in the Brain Antonio Reboreda Prieto 8. Investigation of the Possible Role of TRP Channels in Schizophrenia Loris A. Chahl 9. Investigating Diseases of Dopaminergic Neurons and Melanocytes Using Zebrafish Amanda Decker and Robert Cornell 10. A Practical Guide to Evaluating Anxiety-Related Behavior in Rodents Caitlin J. Riebe and Carsten T. Wotjak 11. Rodent Models of Conditioned Fear: Behavioral Measures of Fear and Memory Jennifer L. McGuire, Jennifer L. Coyner, and Luke R. Johnson 12. Chick Anxiety-Depression Screening Model Stephen W. White and Kenneth J. Sufka 13. A Clinically Relevant Thromboembolic Stroke Model in the Aged Rat Ryan C. Turner, Alisa S. Elliott, Jason D. Huber, and Charles L. Rosen 14. Use of Cell-Stretch System to Examine the Characteristics of Mechanosensor Channels: Axonal Growth/Neuroregeneration Studies Koji Shibasaki 15. Methods in Neuronal Growth Cone Biology Robert J. Gasperini and Lisa Foa Part III: TRPs and Skin 16. Transient Receptor Potential Channels and Pruritus Heike Benecke, Janine Wäring, Tobias Lotts, and Sonja Ständer 17. Skin Sensitivity Studies Laurent Misery 18. Hair Follicle Culture Michael P. Philpott Part IV: TRPs and Metabolic Disorders 19. Animal Models for Type 1 Diabetes Anish Suri and Matteo Levisetti 20. Type 2 Diabetes Models Dorte X. Gram 21. Using Diet to Induce Metabolic Disease in Rodents Angela M. Gajda, Michael A. Pellizzon, and Matthew R. Ricci 22. Rodent Models to Evaluate Anti-Obesity Drugs Sharon Cheetham and Helen Jackson Part V: TRPs: Colitis, Cancer, Thermosensation, and Musculoskeletal Disorders 23. Experimental Colitis Models Patrick A. Hughes, Stuart M. Brierley, Joel Castro, Andrea M. Harrington, and L. Ashley Blackshaw 24. Tumor Xenograft Models to Study the Role of TRP Channels in Tumorigenesis V'yacheslav Lehen'kyi, Sergii Khalimonchyk, Albin Pourtier, Maylis Raphaël, and Natalia Prevarskaya 25. Methods to Study Thermonociception in Rodents Kata Bölcskei 26. Methods for the Assessment of Heat Perception in Humans Michael F. Crutchlow and Joel D. Greenspan 27. Collagen Antibody-Induced Arthritis (CAIA): A Disease-Relevant Model for Studies of Persistent Joint Pain Katalin Sandor, Kutty Selva Nandakumar, Rikard Holmdahl, and Camilla I. Svensson 28. Animal Models of Muscular Dystrophy Yuko Iwata and Shigeo Wakabayashi Katalin Sandor, Kutty Selva Nandakumar, Rikard Holmdahl, and Camilla I.
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EAN: 9781493960668
UPC: 9781493960668
ISBN: 9781493960668
MPN: N/A
Format: Paperback, 489 pages, Softcover reprint of Edition
Author: Arpad Szallasi (Edited by)
Item Height: 2.6 cm
Item Length: 25.4 cm
Item Weight: 1.29 kg
Item Width: 17.8 cm
Language: Eng
Publication Name: N/A
Publisher: Humana Press Inc.
Type: N/A
